Phase I trial with a combination of docetaxel and 153Sm-lexidronam in patients with castration-resistant metastatic prostate cancer
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چکیده
منابع مشابه
Phase I safety and pharmacodynamic of inecalcitol, a novel VDR agonist with docetaxel in metastatic castration-resistant prostate cancer patients.
PURPOSE We conducted a phase I multicenter trial in naïve metastatic castrate-resistant prostate cancer patients with escalating inecalcitol dosages, combined with docetaxel-based chemotherapy. Inecalcitol is a novel vitamin D receptor agonist with higher antiproliferative effects and a 100-fold lower hypercalcemic activity than calcitriol. EXPERIMENTAL DESIGN Safety and efficacy were evaluat...
متن کاملComplete Radiologic Response in Metastatic Castration-Resistant Prostate Cancer Treated with Cabazitaxel
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Phase Ib Study of Enzalutamide in Combination with Docetaxel in Men with Metastatic Castration-Resistant Prostate Cancer.
PURPOSE Preclinical evidence suggests that both docetaxel and enzalutamide target androgen receptor translocation and signaling. This phase Ib study assessed the safety, tolerability, and pharmacokinetics of docetaxel when administered with enzalutamide as first-line systemic chemotherapy in men with metastatic castration-resistant prostate cancer (mCRPC). EXPERIMENTAL METHODS Docetaxel-naïve...
متن کامل(intetumumab) in combination with docetaxel and prednisone for the first-line treatment of patients with metastatic castration-resistant prostate cancer
A randomized, double-blind, multicenter, phase 2 study of a human monoclonal antibody to human a m integrins (intetumumab) in combination with docetaxel and prednisone for the first-line treatment of patients with metastatic castration-resistant prostate cancer A. Heidenreich1,, S. K. Rawal2, K. Szkarlat3, N. Bogdanova4, L. Dirix5, A. Stenzl6, M. Welslau7, G. Wang8, F. Dawkins9, C. J. de Boer10...
متن کاملA phase I-II study of docetaxel and atrasentan in men with castration-resistant metastatic prostate cancer.
PURPOSE The primary aims of this phase I-II study were to determine the maximum tolerated dose, dose-limiting toxicity, pharmacokinetics, and preliminary efficacy of the combination of docetaxel and the endothelin A receptor antagonist atrasentan as first-line treatment for men with metastatic castration-resistant prostate cancer. EXPERIMENTAL DESIGN Patients were treated with docetaxel at do...
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ژورنال
عنوان ژورنال: Urologic Oncology: Seminars and Original Investigations
سال: 2011
ISSN: 1078-1439
DOI: 10.1016/j.urolonc.2009.10.003